Compressor

Effect On/Off: OFF

PreAmp

Effect On/Off: ON
Amp Type: METAL D
Volume: 100
Bass: 88
Mid: 35
Treble: 65
Presence: 90
Master: 95
Gain: MIDDLE

Speaker Simulator

Effect On/Off: ON
Speaker Type: METAL
Mic Setting: 4 cm
Mic Level: 100
Direct Level: 0

4Band Equalizer

Effect On/Off: ON
Effect Type: EQ
Low gain: 8dB
Low-Mid Gain: 8dB
Low-Mid Freq: 6.3kHz
Low-Mid Q: 1
High-Mid Gain: 7dB
High-Mid Freq: 2.0kHz
High-Mid Q: 1
High Gain: 0dB
Level: 0dB

Noise Suppressor

Effect On/Off: ON
Threshold: 25
Release: 1

Comment by contributor

First off - I'm sure you'd agree w/ me that Joe accomplishes that sound through a gazillion different influencing factors such as; guitar, pickups, strings, amp, miking techniques and lastly, but certainly not least, his God-given talent. Having said that - I think people like you and I can accomplish something 'close' by reproducing as much of those basic build blocks as possible. So - last year I ran out and bought a nifty new Satriani model Ibanez (btw, I hate it...;) and attempted to record a composition of my own - in a 'Satriani-ish' style. It's not perfect, but I think captures some 'overtones' of Joe's sound. Here's a URL, if you're interested, of a sample of that guitar sound.
Specs: Ibanez, JS series, Satriani model. 2-double humbuckers. Front hum was used. There's a pull on the volume knob to go to a single-coil sound that was used.
This patch comes from U21(Delayed Lead). Reverb was standard. Again - there's a million things that will effect your final sound - and mine's certainly not perfect. But maybe it's a place to start.